Nrf2, a transcription factor mainly involved in antioxidant defense, regulates the expression of ALR, Augmenter of Liver Regeneration

The liver is frequently challenged by so called metabolic overload, lipid accumulation, viruses or toxins, which induce the formation of reactive oxygen species (ROS). ROS can damage lipids, protein and DNA by peroxidation leading to complete degradation. A crucial player in the defense against oxidative stress is NF-E2-related factor 2 (Nrf2). The transcription factor Nrf2 is important for protecting cells against oxidative damage. It has been shown that Nrf2 binds to the antioxidant response element (ARE) controlling the expression of antioxidant proteins involved in the detoxification of harmful compounds. Ad…