CareLit Fachartikel
Detection of Melanocortin 4 Receptor in rat liver and its regulation during acute phase response
IA Malik, J Triebel, J Posselt, D Raddatz, G Ramadori · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Dokument
922280
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Jahr
2011
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Zusammenfassung
As member of the defense system, liver is inextricably linked with the acute phase response (APR). On the other hand, liver cells may be the target of noxious material released from injured tissue or injuring agents.The melanocortin 4 receptor (MC4R) is known for the mediation of anti-inflammatory signals which controls the production of several pro-inflammatory cytokines. Acute phase reaction was induced in rats by intramuscular injection of turpentine oil (TO). Animals were sacrificed at different time points after injection, blood and liver tissue were taken and frozen immediately. Liver tissue was used for i…
Schlagworte
acute-phase response
cytokines
inflammation
liver
melanocortin
Zeitschrift für Gastroenterologie
