Mycophenolic acid, a possible Inhibitor of re-fibrosis in HCV-positive liver transplanted patients

Background and Aims: The rising number of liver-transplanted patients with chronic HCV-infection makes it necessary to establish a therapy which is profitable in immunosuppression, repression of virus activity, and overall survival. A keystone of liver fibrosis is the activation of human hepatic stellate cells (HSC). Therefore our aim was to analyze the influence of Immunosuppressiva on HSC activity. Methods: Thus we analyzed proliferation of cells by MTT, gene expression (Col1α, TGF-β, α-SMA, PDGF and PUMA), and protein expression (TGF-β, α-SMA, hyaluronic acid [HA]) after incubation of immortalized HSC (LX2-ce…