CareLit Fachartikel
Establishment of a conditional knock out mouse to investigate the function of C4.4A in liver diseases
UM Galli, M Zöller, H Bruns, P Schemmer · Zeitschrift für Gastroenterologie · 2011 · Heft 01
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922286
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Jahr
2011
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Zusammenfassung
The human homolog of a rat metastasis-associated molecule, hC4.4 A, is a glycolipid-anchored membrane protein with structural homology to the urokinase-type plasminogen activator receptor (uPAR). Although C4.4A expression is rather restricted in non-transformed tissues, it has been observed in tumours derived from brain, lung, liver, kidney, stomach and colon. C4.4A is expressed in over 80% of primary colorectal cancer and liver metastasis with negligible expression in adjacent colonic mucosa, inflamed colonic tissue and liver. In addition, mC4.4A expression is strongly up-regulated in migrating keratinocytes du…
Schlagworte
C4.4A
cholangiocarcinoma
cirrhosis
hepatitis
hepatocellular carcinoma
knock out mouse
liver metastases
Zeitschrift für Gastroenterologie
