Proteasomal degradation of the tumor suppressor PML supports HCC development
K Herzer, A Beilfuss, G Kretschmann, S Müller, A Duenbostell, J Sowa, J Ertle, S Biesterfeld, G Gerken, PR Galle, A Canbay · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Hepatocellular carcinoma (HCC), which accounts for 80%-90% of primary liver tumors, is characterised by a very poor prognosis and is associated with high mortality. The molecular mechanisms responsible for development of this tumor are only incompletely understood. We could previously show that the nuclear phosphoprotein PML which has been shown to inhibit cell growth and transformation of tumor cells, plays a role in the regulation of apoptotic factors in hepatocellular carcinoma (HCC). To clarify the clinical implication of PML in HCC, the expression of PML was analysed in a large series of human HCCs. M…
