Association of Mannose-Binding-Lectin-2-gene Polymorphism to the Development of Hepatitis-C-induced Hepatocellular Carcinoma
D Eurich, S Boas-Knoop, R Neuhaus, R Somasundaram, M Rühl, UP Neumann, P Neuhaus, M Bahra, D Seehofer · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background: Development of end-stage liver and graft disease is suspected to be partially determined by individual genetic background. Mannose-binding lectin-2 (MBL-2) is an important immunomodullatory factor, which is supposed to be involved in complement activation and oncogenesis. Genetic polymorphisms of MBL-2 alter the protein functionality. Aim of our study was to determine the prevalence of MBL-2-polymorphism (rs7096206) in HCV-induced hepatocellular carcinoma (HCC) based on histological analysis of explanted livers in patients undergoing liver transplantation. Methods: 177 patients, who underwent liver t…
