CareLit Fachartikel
Strong in vivo antiviral efficacy of a new L-deoxycytidine derivate in hepatitis B virus infected chimeric uPA mice
T Volz, L Allweiss, M Lütgehetmann, A Lohse, E Matthes, J Petersen, M Dandri · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Dokument
922302
CareLit-ID
Jahr
2011
Publikation
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Metadaten
DOI
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Zusammenfassung
Suppression of viral replication with nucleos(t)ide inhibitors has shown to greatly improve the outcome of chronic hepatitis B virus (HBV) infection. L-nucleoside analogues represent one of the most efficient groups of antiviral compounds. Previous studies showed that among these nucleosides, a novel L-hydroxydeoxycytidine compound, the ß-L-2´,3´-didehydro-2´,3´-dideoxy-N4-hydroxy-5-fluorocytidine (L-Hyd4FC) with an ED50=0.05µM displayed the highest selectivity for the HBV polymerase and lack of toxicity in vitro. Aim of this study was to determine the activity of L-Hyd4FC in vivo using uPA/SCID mice harbouring…
Schlagworte
HBV
HBcAg
HBsAg
polymerase inhibitors
uPA/SCID mice
Zeitschrift für Gastroenterologie
