Vascular reverse remodeling in the mouse model of hypoxia-induced pulmonary hypertension – role of AMD-1

Background: Pulmonary hypertension (PH) is a progressive and life-threatening disease, characterized by increased pulmonary vascular resistance. PH can be induced by chronic alveolar hypoxia, which results in a vascular remodeling process, including a thickening of the vessel wall and a reduced vascular lumen. The aim of this study was to investigate whether the pronounced vascular remodeling observed in the mouse model of hypoxia-induced PH could be reversed by re-exposure of animals to normoxia (reverse remodeling). Furthermore we sought to identify new genes that may trigger this process. Methods/Results: Mic…