CARD15 gene haplotypes in sarcoidosis

Introduction: Sarcoidosis is a systematic granulomatous disorder, characterized by an exaggerated chronic inflammatory response to a yet unknown target. Recent aetiological studies indicate that genetic susceptibility could play a central role in the disease development and progression. A possible candidate gene for sarcoidosis is CARD15 due to its potential functional involvement in the pathogenesis and suggested genetic associations with Crohn's disease, Blau syndrome and Early Onset Sarcoidosis, all of which have overlaping clinical and pathological features with sarcoidosis. In this study, we investigated wh…