PET/MRI-based phenotyping of a transgenic rat model for Huntington's disease – a 16 months follow-up study
E. Hölzner, V. Lippross, S. Hermann, N. Nagelmann, J. Heselhaus, S. Bohlen, H. Kugel, M. Deppe, J. Sommer, C. Bremer, H. Nguyen, O. Riess, S. von Hörsten, M. Schäfers, A.H. Jacobs, R. Reilmann · Klinische Neurophysiologie · 2011 · Heft 03
Bibliografische Angaben
Zusammenfassung
Background: The tgHD rat (von Horsten et al. 2003) carries 51 CAG repeats, which is within ranges observed in human genotypes. It was previously reported that small animal FDG-PET is able to detect hypometabolism in the whole brain of tgHD rats at 18–24 months of age. However, this initial imaging study was limited by its cross-sectional nature, the resolution of the small animal PET employed and the lack of a regional analysis. Due to the late-onset development of phenotype in tgHD rats compared to, e.g., the juvenile onset in R6/2 mouse, in-vivo imaging may facilitate phenotype assessment in therapeutic studie…
