Nephrotic syndrome: an unusual manifestation of classical Hodgkin’s Lymphoma in the adolescent

Objective: Hodgkin lymphoma (HL), is a malignant tumor of unknown etiology which is characterized by the presence of clonal multinuclear Hodgkin/Reed-Sternberg cells embedded in a mixture of reactive T-cells, histiocytes, eosinophils and plasma cells. HL has been shown to be associated with various autoimmune phenomena, e.g. autoimmune hemolytic anemia or immune-mediated thrombocytopenia. In about 1% of patients with classical Hodgkin lymphoma (cHL) minimal change nephrotic syndrome (MCNS) is diagnosed which is considered to be an immune-mediated glomerular disease. Recently, aberrant expression of c-mip, a prot…