High inter- and intraobserver inconsistencies in the assessment of MIB-1-based proliferative acitity of breast carcinomas: a survey of the Swiss working group of gynaeco- and brea…
Z Varga, J Diebold, C Domman, H Frick, D Kaup, A Noske, E Obermann, C Oehlschlegel, C Rakocy, S Sancho-Oliver, S Schobinger-Clement, H Schreiber, G Singer, C Tapia, U Wagner, HA Lehr · Senologie - Zeitschrift für Mammadiagnostik und -therapie · 2011 · Heft 06
Bibliografische Angaben
Zusammenfassung
Adjuvant chemotherapy decisions in breast cancer are increasingy based on the pathologist's assessment of tumor proliferation. The Swiss working group of gyneco- and breast pathologists has surveyed the inter- and intraobserver consistencies of MIB-1 immunohistochemistry read-outs. Methods: In a 1st round, 5 pathologists evaluated MIB-1-labeling index (LI) in 10 breast cancers by counting (among 500 tumor cells) and by eyeballing. In a 2nd round, 15 pathologists evaluated MIB-1-LI in three G2 breast cancers by counting and eyeballing, but in predefined fields of interest. In both rounds, MIB-1 was assessed in ce…
