Analysis of the effect of glucose-dependent insulinotropic polypeptide infusion on the gene expression of calcitonin peptides in human adipose tissue

Aims: Increased plasma levels of calcitonin gene-related peptide (CGRP)-I and procalcitonin (Pro-CT) are associated with obesity and inflammation. Glucose-dependent insulinotropic polypeptide (GIP) is recently described to induce CGRP-I and CT expression in human adipocytes in vitro. However, a physiological relevance of the link between GIP and CT peptides has not been studied yet. The aim of the study was the assessment of the effect of the GIP infusion on the expression of CGRP-I and Pro-CT in human adipose tissue. Materials and methods: GIP effects were studied in subcutaneous fat biopsies of seventeen healt…