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TNF-receptor 1 ameliorates disease progression of Nemo-mediated hepatitis

A Singh, FJ Cubero, E Borkham-Kamphorst, M Boekschoten, M Al-Masaoudi, C Liedtke, T Luedde, R Weiskirchen, M Müller, M Heikenwälder, C Trautwein · Zeitschrift für Gastroenterologie · 2011 · Heft 08

Dokument
924508
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Jahr
2011
Publikation
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
A Singh, FJ Cubero, E Borkham-Kamphorst, M Boekschoten, M Al-Masaoudi, C Liedtke, T Luedde, R Weiskirchen, M Müller, M Heikenwälder, C Trautwein
Ausgabe
Heft 08 / 2011
Seiten
–
Erschienen: 2011-08-09 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0031-1285222

Zusammenfassung

Hepatocyte-specific NEMO knockout mice (NemoΔhepa) show that the IκB kinase subunit NEMO/IKKγ is essential for activating NF-κB, which regulates cellular responses during inflammation, cell proliferation and apoptosis. In the present study we aimed to better characterise the protective pathways in death receptor-mediated hepatocyte apoptosis in NemoΔhepa animals. We thus established NemoΔhepaTRAIL-/-, NemoΔhepaTNFR1-/- and NemoΔhepaTRAIL-/-TNFR1-/- and analyzed its consequences on disease progression compared to NemoΔhepa animals. NemoΔhepaTRAIL-/- like NemoΔhepa mice showed increased apoptosis, proliferation, s…

Schlagworte

Zeitschrift für Gastroenterologie