Normalized autofluorescence imaging diagnostics in upper GI tract: a new method to improve specificity in neoplasia detection

Background & aims: To date the autofluorescence imaging (AFI) diagnostics has been successfully applied as adjuvant imaging technique in combination with conventional or high-resolution endoscopic surveillance in the colon and respiratory tract to assist early discover of dysplastic lesions, biopsy guidance and microsurgery navigation. This single-center feasibility study was performed to improve the AFI surveillance examining the upper GI tract by applying a new method of normalized AFI (NAFI) obtained via tri-modal imaging. Materials and methods: Prospectively, 18 patients with suspected esophagus or stomach c…