Drug induced liver injury associated with Flupirtine in 6 cases

Background & aims: Drug-induced liver injury is a frequent diagnostic consideration in daily practice in hepatology. To date, Flupirtine, a non-opioid analgesic, has only been rarely described to cause liver injury. The aim of this case series was to characterize clinical and morphological features of Flupirtine-associated liver injury. Methods: Clinical presentation of six patients with Flupirtine-associated liver injury was reviewed, clinical follow up and review of histological features were performed. Results: Six patients (4 females) presented with clinical signs of hepatitis. All used Flupirtine for pain m…