Antitumor activity of zoledronic acid in primary breast cancer cells determined by the ATP tumor chemosensitivity assay

Introduction: The NeoAzure study has demonstrated that the use of the bisphosphonate zole-dronate in the neoadjuvant setting increases the rate of complete response in primary breast cancer and therefore indicates direct antitumor activity (Coleman et al. 2010). The purpose of this study was to compare the antitumor effect of zolendronic acid with standard chemotherapy in primary breast cancer cells using ATP-tumor chemosensitivity assay (ATP-TCA). Methods: Breast cancer tissues were obtained from patients with breast cancer who underwent primary breast cancer surgery at our institution between 2006 through 2009…