Seröses carcinoma in situ und p53-Signatur beim primären Tubenkarzinom und primären Peritonealkarzinom

Fragestellung: Serous tubal in situ carcinoma (STIC) has been defined as one important precursor of pelvic serous cancer (Folkins et al. 2008, Crum 2009, Lynch et al. 2009). Morphologically, STIC is defined by are cytologic atypia, high proliferative index and strong staining for p53 (Jarboe et al. 2008). Recently, STIC has been reported in about 30% of endometrial serous carcinomas (Jarboe et al. 2009). As a precursor lesion of STIC, characterised by low proliferative index, but p53-accumulation and no cytologic atypia has been defined (Lee et al. 2007). Methode: The present study evaluates the presence of STIC…