Identification of target genes of Parvovirus H-1 (H-1PV) induced cytopathic effects in medulloblastoma

Medulloblastoma patients with poor prognosis have been identified either as suffering from metastasizing disease at the time of intitial diagnosis or by the detection of cytogenetic rearrangements or distinct gene expression signatures within the primary tumor. In these patients survival rates are below 30% implicating the need for new treatment modalities such as oncolytic virotherapy. The rodent parvovirus H-1PV is a non-recombinant oncolytic virus, which is non-pathogenic in humans. Intratumoral H-1PV application had been shown to induce complete long-term regression in vivo in an orthotopic high-grade glioma…