Induction of heme oxygenase 1 in Mdr2ko mice reduces hepatic inflammation, prevents fibrosis progression and supports fibrolysis
R Barikbin, D Neureiter, JW Wirth, A Erhardt, D Schwinge, J Kluwe, C Schramm, G Tiegs, G Sass · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background: Heme oxygenase 1 (HO–1) has been shown to protect mice from acute hepatitis. We now investigated effects of HO–1 induction in a mouse model of chronic liver inflammation (Mdr2 knockout; Mdr2ko; FVB.129P2-Abcb4tm1Bor) with respect to effects on immune cell infiltration and activity and fibrosis formation. Methods: HO–1 was induced in Mdr2ko mice for 7 consecutive weeks. Liver damage was monitored by alanin aminotranferase (ALT) levels. Leukocyte infiltration, leukocyte subsets (e.g. T cells, macrophages, granulocytes) as well as fibrosis formation (collagen, hepatic stellate cells (HSCs)) was visualiz…
