CareLit Fachartikel
More than a serum parameter: Functional relevance of soluble endoglin (solEng)
SK Meurer, AE Wimmer, E van de Leur, R Weiskirchen · Zeitschrift für Gastroenterologie · 2012 · Heft 01
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924740
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Jahr
2012
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Zusammenfassung
Aims: We have previously shown that Endoglin, an accessory receptor for TGF-β1, is highly expressed in hepatic stellate cells (HSC) and Myofibroblast-like cells (MFB) [1]. Additionally, we could show that endoglin is upregulated during transdifferentiation of HSC to MFB and that a soluble form of endoglin (solEng) is generated by shedding in a cultured HSC cellline (CFSC–2G) [2]. Since solEng is increasingly detected in the serum of patients with cirrhosis [3] we asked if solouble endoglin has an impact on signaling in isolated liver cells especially in HSC.Methods and Results: The rat extracellular domain of en…
Schlagworte
TGF-beta co-receptor
TGF-beta1
fibrosis
hepatic stellate cell
soluble Endoglin
Zeitschrift für Gastroenterologie
