Changes of LCN–2 gene expression in different organs in a rat model of tissue damage

Lipocalin–2 (LCN–2) is a secretory protein exists as a 25kDa monomer and known as neutrophil gelatinase associated lipocalin. It is shown to mediate an innate response to bacterial infection by sequestrating iron and known as a marker of kidney damage. We recently showed the LCN–2 expression in rat and mice as compared to different acute phase proteins. The main aim of this study is to analyze the kinetics of LCN–2 serum levels together with gene and protein expression liver in comparison to the other organs in a rat and mouse model of turpentine-oil (TO)- induced sterile abscess. Turpentine oil was injected in…