Downregulation of CD73 surface expression in regulatory as well as effector T cells in chronic HCV infection
I Tóth, AQ Le, P Hartjen, A Thomssen, C Beisel, C Scheurich, V Matzat, S Kummer, S Polywka, C Frenzel, AW Lohse, S Lüth, J van Lunzen, J Schulze zur Wiesch · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Chronically persisting hepatitis C virus (HCV) infection is characterized by a dysfunctional cellular immune response. Here, we investigate the surface expression of CD39 (ectonucleosid triphosphat diphosphorylase), CD73 (5´-ectonucleotidase) and CD26 (dipeptidyl peptidase IV), that are believed to be important T cell differentiation markers and are highly expressed on murine regulatory T cells (Tregs). Together they convert extracellular ATP into ADP, AMP and eventually into adenosine (ADO). And they have an inhibitory effect on the cellular immune response. Methods: PBMC of a cohort of 40 HCV patients we…
