Induction of heme oxygenase 1 by HMG-CoA-Reductase inhibitors interferes with HCV replication
A Wüstenberg, AD Keller, E Lehmann, H Sirma, R Bartenschlager, V Lohmann, C Loscher, M Dandri, G Tiegs, G Sass · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background and Aims: Heme oxygenase 1 (HO–1) induction or over-expression has been shown to interfere with HCV replication. Induction under experimental conditions is obtained by use of cobalt-protoporphyrin-IX (CoPP), which as a heavy metal compound is not acceptable for patient treatment. We investigated anti-viral as well as HO–1 inducing properties of HMG-CoA reductase inhibitors (statins). Methods: HO–1 induction by fluva-, simva-, atorva-, rosuva- and pravastatin in HCV replicon cell lines was measured by real time RT-PCR and Western Blot. HCV replication was analyzed in LucUbiNeo-ET replicon cells, stably…
