RAGE is required for oval cell activation and inflammation-associated mouse liver carcinogenesis
T Pusterla, J Németh, I Stein, L Wiechert, D Knigin, S Marhenke, T Longerich, A Vogel, A Bierhaus, E Pikarsky, J Hess, P Angel · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
The Receptor for Advanced Glycation-End products (RAGE) is a multiligand receptor and member of the immunoglobulin superfamily of surface receptors. RAGE is mainly involved in tissue damage and chronic inflammatory disorders, sustaining the inflammatory response by engagement with damage associated molecular pattern molecules such as S100 proteins and HMGB1. Furthermore, increased expression of RAGE and its ligands were reported in several types of tumors, enhancing tumor progression and metastasis by still unknown mechanisms. Indeed, Rage-deficient mice are protected in different mouse models of chemically indu…
