Depletion of Dietary Iron Alters the Gut Microbiome and Prevents Crohn's Disease-Like Ileitis

Iron and inflammatory bowel disease (IBD) The pathogenesis of IBD has been attributed to both intestinal bacteria and environmental factors that trigger disease in a genetically predisposed host. One third of IBD patients develop anaemia due to an inappropriate intake or loss of iron affecting life quality (a.o. fatigue, nausea, anorexia, weight loss, dizziness, tinnitus, reduced attention). Anaemia can occur because of iron deficiency (ID) or as anaemia of chronic inflammation/disease (ACI/D) mostly mediated by pro-inflammatory IL-6 which induces hepcidin production leading to a decrease of iron export from cel…