Decreased Dopamine D2/D3-Receptor Binding in the Temporal Lobe and the Bilateral Basal Ganglia in patients with Temporal Lobe Epilepsy
VE Bernedo Paredes, H Schwartz, M Gartenschläger, M Gartenschläger, HG Buchholz, M Breimhorst, M Schreckenberger, KJ Werhahn · Klinische Neurophysiologie · 2012 · Heft 03
Bibliografische Angaben
Zusammenfassung
Dopamine is an endogenous neuromodulator in cortical circuits and basal ganglia. In animal models, it is known to affect seizure threshold and might have a neuroprotective role in temporal lobe epilepsy (TLE).1 In animal models of TLE activation of D1- has a pro- and of D2-receptors (D2R) an anticonvulsant effect. To quantify D2/D3 receptor binding we studied 26 patients with TLE and 18 controls by PET using the high affinity dopamine D2/D3 receptor ligand 18F-Fallypride ([18F]FP) suitable for imaging extrastriatal binding. TLE was defined by interictal and ictal video-EEG, MRI and 18F-Fluorodesoxyglucose-PET. A…
