Age dependent de-differentiation across functional domains

Introduction: There is evidence that functional specialisation of the human cerebral cortex decreases with age (Park et al., 2004). Evidence for this process, known as de-differentiation, was provided so far only by examination of individual functional networks (Park et al. 2010). On the other hand, little is known about similar mechanisms during cross-modal processing. The present study examined potential age related de-differentiation across two cognitive domains by assessing aging effects of motor control and selective attention. Methods: 101 right-handed healthy adults (49 female) with a balanced age distrib…