Traditional herbal drugs with antiadhesive activity against uropathogenic Escherichia coli (UPEC)

Background: UPEC causes about 80% of uncomplicated urinary tract infections (UTIs). After entering the opening of the urethra, the first step of the infection is mediated by different virulence factors. Outer membrane proteins (type 1 fimbriae, P-, S-, and F1C-fimbriae) adhere specifically to oligosaccharides on the bladder mucosa, followed by invasion into the host cells. UTIs have a high recurrence rate. Within the exploration and assessment of therapeutic alternatives the prophylaxis of a potential infection by antiadhesive compounds is getting more and more into the experimental and clinical research focus.…