Airway region-specific effects of Carbon Black nanoparticles

Introduction: Carbon Black nanoparticles (CBNPs), less than 100nm in size, are present in industrially produced carbon black mainly used for reinforcement of elastomers (e.g. in tyres) but also for paints, varnishes, toner and batteries. Upon inhalation CBNPs may have toxicological and inflammatory effects on the lung such as epithelial cell death or proliferation, persistent inflammation, fibrosis and even lung cancer. The effects of CBNPs could be mediated by oxidative stress, pro-inflammatory and pro-fibrotic cytokines and/or expression of genes responsible for cell proliferation. The commercially available C…