The effect of endotoxin on cell-proliferation and responsiveness to treatment in Non-small-cell-lung-cancer

Pulmonary infections are common complications in patients with lung cancer and worsen prognosis. The most common pathogens found in patients with lung cancer are gram-negative bacteria whose virulence is caused by the components of the cell wall, especially by gram-negative LPS. For this reason we analysed, if endotoxin would activate cell-proliferation and moreover we wanted to know if sensitivity to radio- and chemotherapy, is modified by endotoxin. Three human non small cell lung cancer (NSCLC) cell lines, A549 (adenocarcinoma), H23 (adenocarcinoma) and H226 (squamous epithelium carcinoma) were incubated with…