Regulation of pulmonary arterial smooth muscle cell function in pulmonary hypertension via Paxillin

Pulmonary hypertension is characterized by a pronounced remodeling process of the pulmonary vasculature. Pulmonary hypertension (PH) is a life threatening disease characterized by a pronounced remodeling of the pulmonary vasculature. The remodeling process entails increased proliferation of pulmonary arterial smooth muscle cells (PASMC), deposition of extracellular matrix and dysregulation of cytoskeletal proteins. However, the contribution of cytoskeletal proteins in pulmonary vascular remodeling is still not fully understood. In this study we screened for novel binding partners of the cytoskeletal adaptor prot…