Sensitivity of primary Glioblastoma cell lines towards Cilengitide alone and in combination with Temozolomide

Glioblastoma multiforma (GBM) still has a very poor prognosis even with today's aggressive combination therapy of resection followed by radio-chemotherapy with Temozolomide. It is mainly characterized by an enormous high level of tumor vascularization and infiltrative growth.In both these processes, integrins play an important role as transmembrane heterodimeric glycoproteins mediating the interaction between cells and the extracellular matrix. Especially the subtypes αvβ3 and αvβ5 are currently identified to be expressed on both tumorinvasive endothelia and Glioblastoma cells. Recent clinical data support a pos…