FOXO transcription factors regulate innate immune functions in respiratory epithelial cells
F Seiler, J Hellberg, PM Lepper, A Kamyschnikow, C Herr, M Bischoff, F Langer, HJ Schäfers, F Lammert, MD Menger, R Bals, C Beisswenger · Pneumologie · 2012 · Heft 11
Bibliografische Angaben
Zusammenfassung
Aims: Bacterial infections are a leading cause of acute respiratory tract pathology and aggravate chronic inflammatory diseases such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). To defend against bacterial pathogens, the respiratory tract evolved a potent innate immune system, which includes innate immune functions of epithelial cells. Recent studies have linked FOXO to innate immunity. FOXO transcription factors are pivotal modulators of cellular metabolism, proliferation, survival and stress resistance. Here we investigated the role of FOXO in promoting innate immune functions in r…
