Combination of psychosocial stress and a NASH-inducing diet in mice

A sedentary life stile combined with high calorie intake is the major cause of non-alcoholic fatty liver disease (NAFLD). This life style often coincides with chronic psychosocial stress. The aim of this study was to characterize the effect of a model of chronic psychosocial stress on liver physiology and to combine it with a dietary model of non-alcoholic steatohepatitis (NASH) in mice. Methods and Results: Chronic psychosocial stress was induced in male C57BL/6 mice by chronic subordinate colony (CSC) housing, a preclinically validated paradigm relevant for human psychiatric and somatic disorders. Thereby, fou…