Gallstone disease is linked to the Gilbert-Meulengracht UGT1A1*28 variant: case-control analysis of Swedish twins

Background and Aims: The Gilbert-Meulengracht syndrome-associated functional TATA box variant UGT1A1*28 (A(TA)7TAA) increases susceptibility to pigment gallstone formation in the setting of haemolytic anemias [1]. Latest studies demonstrated that carriers of this variant bear an increased risk of cholesterol stones as well [2]. Here we investigate the UGT1A1 variant as a determinant of gallstone disease in a unique cohort of Swedish Twins. Patients and Methods: The Swedish Twin Registry was merged with the Hospital Discharge and Causes of Death Registries for gallstone disease-related diagnoses and screened for…