Hedgehog signalling pathway is involved in the regulation of circadian rhythm within hepatic lipid metabolism

Entrained and reset by external cues, the internal circadian clock controls innate physiological processes, including liver metabolism. At the cellular level the circadian clock is characterised by a variety of core clock genes, which, acting as transcriptional factors, modulate the fluctuating expression of central metabolic genes [1] Presenting an extensive biological process the clock is linked to the elements of the cell cycle control and intracellular signalling pathways. Recent analyses identified the hedgehog (HH)-signalling also to be associated with liver clock [2]. Being an evolutionary highly conserve…