Response to vitamin D substitution in patients with chronic liver disease and different baseline levels

Background: Patients with chronic liver disease (CLD) frequently exhibit vitamin D deficiency1 and related extrahepatic manifestations such as hepatic osteodystrophy2. Intervention studies with vitamin D in CLD patients have yielded inconsistent results, which may be attributed to baseline vitamin D status and/or inadequate dosage. The suggested sigmoid response to treatment may in part explain these inconsistencies, where low basal status or intake produce a negligible response compared to higher basal levels and/or dosage3. Herein, we assess the effectiveness of an oral vitamin D3 formulation for restoring sub…