Downregulation of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) in human cholangiocellular carcinoma and their prognostic significance
A Graesel, A Lautem, M Heise, J Knapstein, JM Schattenberg, G Otto, H Lang, PR Galle, M Schuchmann, T Zimmermann · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Bibliografische Angaben
Zusammenfassung
Introduction: The cholangiocellular carcinoma (CCC) is a primary hepatic malignancy derived from cholangiocytes. The prognosis for CCC is very poor and conventional chemotherapy is not effective in prolonging long-term patient survival rates. The organic cation transporters OCT1 and OCT3 mediate the transport of a broad spectrum of endogenous substrates and the detoxification of xenobiotics. Moreover, OCTs are held responsible for the responsiveness towards platin-containing chemotherapies. No data exist about the relevance of OCTs in CCC. Therefore, the aim of this study was to examine the expression of OCT1 an…
