Thyroid dysfunction induced by Peginterferon alfa-2B (PEG-2B)/Ribavirin (RBV) is a favorable predictor of SVR in patients with HCV genotype 1 (G1), but not HCV genotype 2/3 (G2/3)…
S Mauss, D Hüppe, E Zehnter, MP Manns, G Teuber, T Dahhan, U Meyer, T Witthöft, B Möller, N Dikopoulos, J Brack, B Stade, M Bilzer · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background: Thyroiditis leading to thyroid dysfunction in patients undergoing treatment for chronic HCV infection has been attributed to interferon-stimulated immune mechanisms similar to that implicated in the antiviral response induced by interferons. Here, the possible association between thyroid dysfunction related to Peg2b/RBV and the virologic outcome of patients treated for G1 and G2/3 infection was investigated. Methods: Data from patients treated for G1 (N=1923), G2 (N=250) and G3 (N=1117) infection with Peg2b 1.5µg/kg/week + weight-based RBV (800–1200mg/day) for up to 48 weeks in a large observational…
