Role of TNFAIP2 in Legionella pneumophila-induced pulmonary inflammation

Legionella pneumophila (L. pneumophila) is an important causative agent of severe pneumonia in humans. The human alveolar epithelium and macrophages constitute the main cellular targets for inhaled microorganisms and play a key role in the initiation of the innate immune response and the defence against respiratory infection. Recent studies have highlighted an important role for chromatin modifications in controlling the expression of inflammatory genes. Hence, human alveolar epithelial cells (A549) were infected with L. pneumophila, and polymerase II recruitment and acetylation of histone H4 were analyzed in a…