The role of microRNAs in the regulation of adipogenesis

Aims: MicroRNAs (miRNAs) are a family of short, endogenously expressed, non-coding RNAs which regulate gene expression, particularly in developmental processes. Recent studies indicate a critical role in adipocyte differentiation. Objective: In this study we investigated the effect of inhibition of miRNA processing on adipocyte differentiation. Furthermore, we searched for miRNAs that are differentially regulated during human adipocyte differentiation and their putative target genes. Methods: In vitro experiments were performed in human Simpson-Golabi-Behmel syndrome (SGBS) cells, a cell model for adipogenesis.…