CareLit Fachartikel

Challenges in planning and conducting diagnostic studies with molecular biomarkers

N.N. · DMW - Deutsche Medizinische Wochenschrift · 2013 · Heft 19 · S. e14-e24

Dokument
929028
CareLit-ID
Jahr
2013
Publikation
PDF
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Metadaten
DOI
ja
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Bibliografische Angaben

Zeitschrift
DMW - Deutsche Medizinische Wochenschrift
Autor:innen
N.N.
Ausgabe
Heft 19 / 2013
Jahrgang 138
Seiten
e14-e24
Erschienen: 2013-05-01 00:00:00
ISSN
0012-0472
DOI
10.1055/s-0033-1343172

Zusammenfassung

Abstract Biomarkers are of increasing importance for personalized medicine in many areas of application, such as diagnosis, prognosis, or the selection of targeted therapies. In many molecular biomarker studies, intensity values are obtained from large scale –omics experiments. These intensity values, such as protein concentrations, are often compared between at least two groups of subjects to determine the diagnostic ability of the molecular biomarker. Various prospective or retrospective study designs are available for molecular biomarker studies, and the biomarker used may be univariate or even consist in a m…

Schlagworte

biomarker coefficient of variation diagnostic study molecular diagnostics sampling bias validation verification bias DMW - Deutsche Medizinische Wochenschrift