CareLit Fachartikel

Influence of zoledronic acid on disseminated tumor cells in bone marrow and survival: results of a prospective clinical trial

M Banys, E Solomayer, G Gebauer, W Janni, H Lueck, S Becker, J Huober, B Krämer, B Wackwitz, P Hirnle, D Wallwiener, T Fehm · Senologie - Zeitschrift für Mammadiagnostik und -therapie · 2013 · Heft 06

Dokument
929308
CareLit-ID
Jahr
2013
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Senologie - Zeitschrift für Mammadiagnostik und -therapie
Autor:innen
M Banys, E Solomayer, G Gebauer, W Janni, H Lueck, S Becker, J Huober, B Krämer, B Wackwitz, P Hirnle, D Wallwiener, T Fehm
Ausgabe
Heft 06 / 2013
Seiten
–
Erschienen: 2013-06-04 00:00:00
ISSN
1611-6453
DOI
10.1055/s-0033-1347542

Zusammenfassung

Introduction: The presence of disseminated tumor cells (DTC) in bone marrow (BM) of breast cancer patients is associated with reduced clinical outcome. Bisphosphonate treatment was shown to eradicate DTC. This controlled study aimed to investigate the influence of zoledronic acid (ZOL) on DTC and survival of breast cancer patients. Methods: Patients with primary breast cancer and DTC-positive bone marrow were randomized to treatment with ZOL plus adjuvant systemic therapy (n = 40) or adjuvant systemic therapy alone (n = 46). DTC were identified by immunocytochemistry using the antibody A45B/B3. The change in DTC…

Schlagworte

Senologie - Zeitschrift für Mammadiagnostik und -therapie