Hypoxia alters syncytiotrophoblastic microparticles (STBM)-related coagulation capacities

Introduction: Endothelial dysfunction, defined as vasoconstiction and platelet activation, is thought to be the cause of preeclampsia (PE) symptoms. Especially severe forms of the pregnancy-associated pathology PE is correlated to the release of syncytiotrophoblastic microparticles (STBM), which triggers inflammatory processes on the endothelium. The thrombogenic potential of STBMs, however, are not well characterized. Aim of the study was to investigate the pro-coagulant activity of STBMs. Methods: STBMs were derived from placentae perfused under norm- and hypoxic conditions and quantified with our house-“ELSA.…