G-protein-coupled receptor GPR30 expression as a prognostic factor in breast cancer patients

Purpose: GPR30 is a member of the superfamily of G-protein-coupled receptors and mediates rapid „non-classic” estrogen actions. This study was performed to examine GPR30 protein expression in breast cancer specimens and normal breast tissue. Furthermore, we investigated the prognostic value of GPR30 in breast cancer patients. Methods: GPR30 protein expression was examined immunohistochemically in 164 primary breast cancer specimens and their matched normal breast epithelium and this relationship was correlated to different clinicopathological characteristics. Additionally, GPR30 expression was examined in 38 duc…