Gene-set based analysis for alcohol dependence
J Treutlein, D Juraeva, H Scholz, J Frank, M Ridinger, K Mann, F Kiefer, M Nöthen, B Brors, R Spanagel, M Rietschel · Suchttherapie · 2013 · Heft 09
Bibliografische Angaben
Zusammenfassung
Einleitung: Formal genetic studies have shown that the heritability of alcohol dependence is 40 – 60%, with many common variants contributing. However, as due to multiple testing these often do not pass the threshold of genome-wide significance, it is not clear which genes actually contribute. A supplementary approach is to test sets of related genes, e.g., those which are circumscribed by categories derived from prior biological knowledge. Here, we report results of a gene-set based analysis for alcohol dependence in our previously reported GWAS from the German population. Methode: 1333 cases and 2168 controls…
