Reduced expression of complement regulators CD55 and CD59 on peripheral blood cells is not involved in development of hemolytic uremic syndrome in patients with EHEC O104:H4 infec…
W Dammermann, P Schipper, S Ullrich, K Fraedrich, J Schulze zur Wiesch, T Fründt, G Tiegs, A Lohse, S Lüth · Zeitschrift für Gastroenterologie · 2013 · Heft 08
Bibliografische Angaben
Zusammenfassung
Aims: An outbreak of Shiga Toxin 2 (Stx-2) producing enterohemorrhagic E.coli (EHEC) O104:H4 infection in May 2011 caused enterocolitis and an unprecedented high 22% rate of hemolytic uremic syndrome (HUS). The monoclonal anti-C5 antibody Eculizumab (ECU) has been used experimentally in EHEC patients with HUS but treatment efficacy is uncertain. ECU can effectively prevent hemolysis in paroxysmal nocturnal hemoglobinuria (PNH) caused by a lack of complement-regulating CD55 and CD59 on blood cells. We hypothesized a low expression of CD55 and CD59, as seen in atypical HUS in PNH, might correlate with HUS developm…
