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Mutational analysis of biomarker samples from the CORRECT study: Correlating mutation status with clinical response to regorafenib

A Stein, M Jeffers, E van Cutsem, AF Sobrero, S Siena, A Falcone, M Ychou, Y Humblet, O Bouche, L Mineur, C Barone, A Adenis, J Tabernero, T Yoshino, HJ Lenz, RM Goldberg, D Laurent, A Wagner, A Grothey · Zeitschrift für Gastroenterologie · 2013 · Heft 08

Dokument
929508
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Jahr
2013
Publikation
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
A Stein, M Jeffers, E van Cutsem, AF Sobrero, S Siena, A Falcone, M Ychou, Y Humblet, O Bouche, L Mineur, C Barone, A Adenis, J Tabernero, T Yoshino, HJ Lenz, RM Goldberg, D Laurent, A Wagner, A Grothey
Ausgabe
Heft 08 / 2013
Seiten
–
Erschienen: 2013-08-16 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0033-1352702

Zusammenfassung

Aims: In the CORRECT Ph3 trial, regorafenib demonstrated significant improvement in OS and PFS vs. placebo in subjects with metastatic colorectal cancer (mCRC) who had progressed on standard therapies. An exploratory biomarker substudy was conducted on samples collected from subjects enrolled in CORRECT. Methods: DNA was isolated from archival tumor tissue and fresh baseline plasma samples that were available from 239 (31%) and 503 (66%) subjects enrolled in CORRECT, respectively. Mutations in KRAS, PIK3CA and BRAF were evaluated via BEAMing technology. Results: Mutations were readily detected in DNA isolated fr…

Schlagworte

Zeitschrift für Gastroenterologie