Assessment and topographical analysis of the total histamine degradation capacity (THDC) at the lower GI-tract
C Reiser, E Tietz, A Missbichler, G Frost, G Manz, R Rieker, A Hagel, J Kressel, M Neurath, M Raithel · Zeitschrift für Gastroenterologie · 2013 · Heft 08
Bibliografische Angaben
Zusammenfassung
Aims: Irritable bowel syndrome (IBS) may cause various symptoms including abdominal pain, diarrhoea, constipation and is often associated with food intolerances. Material and methods: To further evaluate the biological capacity of the GI-mucosa to degradate histamine 96 samples from the lower GI tract were homogenized and quantitative histamine degradation followed at different time points (0,8,12,20 min). Samples were taken from 24 patients with either IBS symptoms or known food allergy from ileum, cecum, colon ascendens and sigmoid. Histamine was measured by ELISA, THDC given as median (25 – 75%) ng histamine/…
